EFFECTS OF EXERCISE THERAPY ON FUNCTIONAL CONNECTIVITY IN PARKINSON’S DISEASE by Chintan Shah Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science Department of Biomedical Engineering
نویسنده
چکیده
...............................................................................................................................1 Background and Significance ..............................................................................................2 Parkinson’s Disease ..........................................................................................................2 Exercise and PD ...............................................................................................................2 Functional Connectivity fMRI (fcMRI) ...........................................................................4 Resting State Functional Connectivity in PD ...................................................................5 Significance and Objectives .............................................................................................6 Research Design and Methods .............................................................................................7 Experimental overview: ...................................................................................................7 Study sample: ...................................................................................................................7 Exercise Intervention: ......................................................................................................8 Motor Assessment: ...........................................................................................................9 MRI Data acquisition: ......................................................................................................9 Task performance analysis .............................................................................................11 Image Post Processing ....................................................................................................15 Motion Analysis .............................................................................................................16 Image Analysis ...............................................................................................................17 Second level statistical analysis .....................................................................................21 Results ................................................................................................................................23 Subject demographics ....................................................................................................23 Task performance ...........................................................................................................24 Motion Analysis .............................................................................................................30
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